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1 Introduction 1.1 Atherosclerosis and coronary artery disease Coronary artery disease (CAD) is a cardiovascular condition occuring due to atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive ( Inflammation plays a key role in the formation of atherosclerotic plaquesthe primary pathological mechanism underlying CAD ( (IFN- ) and tumour necrosis factor (TNF)- , produced by immune cells, endothelial cells, platelets and fibroblasts are associated with atherosclerosis onset and progression

Oxyntomodulin is a peptide hormone released from the endocrine L-cells of the gut that activates both GLP1R and glucagon receptors

Our lead clinical programs drug candidate, VK2735, is being developed in both oral and subcutaneous formulations for the potential treatment of various metabolic disorders such as obesity

This rapid growth brings incredible opportunities but also intense competition