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The same group has been administered with 1.75 mg/kg of losartan in single and muliple dose treatments as conducted in rats at 0 (predose), 1, 2, 3, 4, 6, 8, 12, 18, and 24 h Blood samples were collected after drug administration by puncturing the left marginal ear vein and estimated for blood sugar, insulin, and serum glimepiride

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