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Description
The design of future clinical trials for GLP-1 receptor agonists (GLP-1RAs) targeting AD and PD may necessitate distinct approaches
Structural pharmacology and mechanisms of GLP-1R signaling
The ongoing CVOT of tirzepatide (SURPASS-CVOT, NCT04255433) will compare tirzepatide with dulaglutide 1.5 mg/wk to determine efficacy for the primary outcome of 3-point MACE [70]
In terms of Deviations from the intended interventions (D2), one study presented a high risk of bias (50), while two studies indicated some concerns (41, 51)
