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Clinical trial registration: ClinicalTrials.gov identifiers NCT03548935 (STEP 1), NCT03552757 (STEP 2), NCT03611582 (STEP 3), NCT03548987 (STEP 4), and NCT03693430 (STEP 5)

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Incretins and their synthetic mimetics offer benefits by influencing the appetite and satiety centers in the brain, potentially resetting the bodys fat mass and body weight setpoints that are associated with the interplay between orexigenic and anorexigenic signaling pathways

Pregnancy, breastfeeding, adolescence, older age, intensive training, or recovery from illness or surgery