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The GIP receptor agonism adds a complementary mechanism that further enhances insulin secretion and may have additional metabolic benefits including effects on fat metabolism and energy expenditure
And a big reason behind that confidence could be weight loss
While 68 weeks provides a reasonably strong safety profile, it does not answer questions about what happens over 3, 5, or 10 years of continuous use
Oral semaglutide bioavailability is approximately 0.8% in humans, compared to approximately 89% for subcutaneous injection requiring much higher oral doses (3-25 mg oral vs
