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In landmark trials such as LEADER and SUSTAIN-6, liraglutide significantly lowered the risk of cardiovascular death, non-fatal myocardial infarction, and stroke by 13% compared to placebo (Marso et al., 2016a)

However, their usefulness is limited by the risk of edema, heart failure, hepatotoxicity and possible cardiovascular effects[37]

It is important to emphasize that the role of early worsening in individuals without diabetes remains poorly understood

In patients with pancreatic cancer, 43.3% were GLP-1Rnegative (13 of 30) and, in GLP-1Rpositive tissues, tumor size was inversely correlated with GLP-1R expression