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Development of unimolecular agents targeting both GIPR and GLP-1R The anti-obesity effects of GIPR antagonism antibody, both alone and in combination with GLP-1RAs, have been demonstrated in preclinical models of mice and monkeys (68, 73)

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He had carried decades of shame that dissolved in that moment of understanding

Overall, the multimorbidity of depression and T2DM involves shared genetic risk factors and multiple underlying biological mechanisms, including HPA axis dysregulation, pro-inflammatory states, gut-brain axis interactions, and insulin signaling alterations, which can affect neurotransmission