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Nonexpression of GLP-1R is common in advanced pancreatic tumors with lymphatic metastasis and is associated with poor prognosis, suggesting that GLP-1R may inhibit tumorigenesis and metastasis of human pancreatic cancer cells both in vitro and in vivo

Under these conditions, systemic metabolism increasingly relies on lipid-derived substrates and elevated oxidative throughput

Response-Based Approach: Treatment duration is individualized based on objective measurements including body composition analysis (DEXA scan, bioimpedance), waist circumference, metabolic markers, and subjective response