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Others may need it long-term, similar to how people with hypertension or high cholesterol may need ongoing treatment

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These uses of GLP-1RA beyond the proven use in treatment and prevention of cardiovascular risk with obesity (110) as well as in diabetics add a new dimension to use them in early
164,165,166,167 Similarly, DNA damage induces the relocalization of NAD + -dependent deacetylase SIRT1 to DNA breaks, which promotes DNA repair via opening the chromatin and recruiting the main DNA repair factors including KU70, NBS1, WRN, KAP1, XPA and APEX1
