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These benefits are reflected in the clinical guidelines published by the American Diabetes Association (ADA) and the American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE), which recommend use of a GLP-1RA or a sodium-glucose co-transporter-2 inhibitor (SGLT2i) with demonstrated CV risk reduction in patients with established/high risk of atherosclerotic CVD (ASCVD), while considering patient-specific factors [15, 17]

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It is now fascinating to see Lilly and Novo-Nordisk scrapping over Ozempic for diabetes, aka Wegovy for weight loss and Mounjaro for diabetes, aka Zepbound for weight loss

Current recommendations Despite the reassuring data, current guidelines still advise caution