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In addition, a dedicated clinical pharmacology trial observed no clinically relevant effect of renal impairment on exposure after adjusting for covariates (age, sex, and body weight) [38]

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Thus, incretin therapy influences not just metabolism but also sensory and reward pathways. Taste changes tied to satiety, appetite In multivariable analysis, adults who reported increased intensity for sweet taste had higher odds of increased satiety (adjusted OR = 2.02

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